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Research References and Source Context These references are included for chemical identity, pathway or study-context reading

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Tirzepatide, the active ingredient in Zepbound, works by activating both GLP-1 and GIP receptors in your brain and gut, making it roughly twice as potent as semaglutide-only therapies

In cases of intolerable side effects despite management strategies, dose reduction or discontinuation may be necessary

These effects are most pronounced during dose escalation and typically improve with time