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An in silico screening of a homology model of IRAP based on the crystal structure of LTA4H (Leukotriene-A4 hydrolase) was applied (Thunnissen et al., 2001)
This is due to the fact that in CGD the production of the ROS, hydrogen peroxide, is deficient and so these catalase-positive microorganisms can defeat the limited levels of ROS produced by phagocytic cells
J Physiol 2012;590:3009-3017
Kanbay, M
Zhang D, Song S, Lin J, Ye T,Yang X,Jiang Q,Mi Y,Zhang M, Ge X,Shen Y,Du P,Shi Y, Zhang X, Li L, Zhang Y, Ding L, Liu J, Zhang
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