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GLP-1 receptor agonists (GLP-1-RA) were first developed for the treatment of type-2 diabetes, but have been recently approved for treatment of obesity
One such peptide gaining attention is BPC-157 (Body Protection Compound-157) , studied for its anti-inflammatory, tissue-repair, and healing-support properties
For HIF transcription factors, this occurs by hydroxylation at conserved proline residues by prolyl hydroxylases under normoxia, allowing their recognition and ubiquitination by the VHL E3 ubiquitin ligase, which targets HIFs for proteasomal degradation
Similar results were obtained in models of medial collateral ligament and quadriceps injuries
His GI had already ruled out strictures and complications
