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Chen et al (119) used high levels of GSH reductase in the TME and showed that the disulfide bond (-SS-) in SSBPEI-DOX could be specifically reduced, allowing it to bind to the conventional chemotherapeutic drug DOX and induce apoptosis or necrosis of CSCs
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1 Both figures represent substantial weight loss
Rare but serious reactions include chest pain, irregular heartbeat, or paradoxical bronchospasm (worsening wheeze), all of which require immediate medical attention
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