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Studies show that many people regain some weight after stopping tirzepatide, and this pattern has also been seen with other GLP-1 medications

Yamamoto K, Okano H, Miyagawa W, Visse R, Shitomi Y, Santamaria S et al (2016) MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1