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To address these constraints, most reported blood workflows incorporate an upstream seed enrichment step (e.g., immunoprecipitation of Syn species, capture of neuron-enriched EV fractions, or other affinity-based concentration steps) followed by RT-QuIC readout, with performance dependent on both enrichment efficiency and downstream reaction conditions [30]
Earlier studies have found that combination therapy with an SGLT2 inhibitor and a GLP-1 RA, compared with monotherapy with either drug alone, is associated with improved control of cardiovascular risk factors, including a greater reduction of HbA 1c , BP and body weight, demonstrating additive effects [16,17,18]
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Therefore, particularly for these drugs, frequent updates are essential to accurately assess the drugs long-term benefits
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