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Boston, MA: Springer US
evoke and evoke+: design of two large-scale, double-blind, placebocontrolled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomatic Alzheimers disease
The initial dose is 3 mg by mouth once daily for 30 days
A CBC, iron studies, Vitamin B12, Folate, and Vitamin D may be considered according to dietary pattern, weight-loss rate, symptoms, and medical history
[7] [12] However, Phase 2 trials are not powered to detect rare cardiovascular outcomes, and longer-term Phase 3 data including dedicated cardiovascular outcome trials will be essential to fully characterise the cardiac safety profile of retatrutide
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