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In placental tissues obtained from offspring of obese parents, DNA hypermethylation dysregulated the expression of histone deacetylase 4, (HDAC4), which modulates fat cell expansion, promotes energy utilization and protects from excessive weight gain [174,175,176,177] This dysregulation could elevate metabolic disease risk in offspring later in life [174]
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Ndrepepa G, Colleran R, Kastrati A
Clinical studies commonly use this dosage range for athletic performance, fat metabolism, and recovery support
Duration: 46 weeks loading phase, then maintenance every 24 weeks
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