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doi: 10.1093/gerona/glaa185 74 AzzolinoDArosioBMarzettiECalvaniRCesariM
PHASE II DRUG METABOLISM: Glucuronidation and SulfationGeneral properties of Phase II metabolismIntroduction to glucuronidationSubstrates for UGTsUGT structureProperties of glucuronidesMethods to characterize glucuronidesDisposition and reactions of glucuronidesUGT pharmacogenetics, polymorphism, variabilitySulfotransferasesN-Acetylation, Aminoacid conjugation, Glutathione conjugationSmith, Phase II Metabolism, UNC Chapel Hill, 8/2012 1 Conjugation Reactions Some DefinitionsGlucuronidation conjugation is the addition of a molecule to the drug or xenobioticGSH conjugation GSH = glutathione (a tripeptide derivative)Sulfate conjugationAmino acid conjugation Some confusing terminology, both related to drugs:Acetylation Phase 1, Phase 2, Phase 3 are designations used in theMethylation sequence of drug development and evaluation by FDA in the US
Current data about vitamin D, selenium, L-carnitine and [PMID: 23654153] Laboratory literature summary: [Micronutrients in oncology
Wallace DJ, Linker-Israeli M, Hallegua D, Silverman S, Silver D, Weisman MH
With growth hormone secretagogues, the usual outcome is not a dramatic complication
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