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Since the last decade, increasing studies have confirmed that ncRNAs play pivotal roles in various tumors development by targeting diversified downstream genes and signaling pathways and serve as tumor suppressors or stimulators (Higashio et al., 2007

The most common protocol in use today is to administer at night, over a 10-15 day period and repeat the process twice a year

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Despite its growing popularity, it remains important to understand the safety profile, especially for long term use

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