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The mechanisms differ melanocortin receptors internalise in response to sustained agonist binding, while GLP-1 receptors maintain therapeutic responsiveness during long-term administration
Additional information Competing interests The authors declare no competing financial interest
Our findings also affirm prior reports that increasing intracellular glutamate concentration in presynaptic terminals leads to greater excitatory post synaptic currents (EPSC) (29, 30)
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