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In contrast, subcutaneous fat , especially in the hips and thighs, exhibits greater alpha2-adrenergic activity and firmer connective tissue, making it harder to shrink quickly

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Then, gradually increase it

Safety Considerations and Who This Treatment Applies To GLP-1 therapy is generally safe for hypothyroid patients on stable thyroid replacement, but contraindications include personal or family history of medullary thyroid cancer, multiple endocrine neoplasia type 2 (MEN2), or severe pancreatitis

Dietetic support, psychological counselling for eating behaviours, and structured physical activity programmes can enhance and maintain the benefits achieved with medication