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FDA Warns About Rare Occurrences of a Serious Infection of the Genital Area With SGLT2 Inhibitors for Diabetes | FDA

Phase 2 trial results have shown promising efficacy in reducing liver fat content and improving lipid profiles

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The intermediates from de novo lipogenesis in the liver will disrupt mitochondrial function and produce ROS, and then cause endoplasmic reticulum (ER) stress, ultimately leading to inflammation, and the broken cells releasing cytokines will cause more cell death ( The excess free fatty acids (FFAs) and de novo lipogenesis would break the homeostasis of lipid metabolism

A 2024 study (Wadden et al., Obesity ) tracked patients in SURMOUNT-1 who missed exactly one dose during the 72-week trial (n=183 patients)