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ROS includes molecules such as superoxide anion (O 2 ), hydrogen peroxide (H 2 O 2 ), singlet oxygen ( 1 O 2 ), and hydroxyl radicals (OH), 101,102 which can impair mitochondrial function by damaging mtDNA, proteins, membrane lipids, and other cellular components
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One works top-down from the pituitary, the other works bottom-up at the cellular level
Citation [1] Park JR, Lee H, Kim SI, Yang SR
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