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Being on bupropion provides some neurochemical buffer against this destabilization, but it does not eliminate it entirely

The New England journal of medicine , 384 (11), 9891002

In terms of opioids, reportedly 22.3% of the 2.5 million Americans with OUD have received treatment with an OUD indicated medication in the past year (though some estimates put the number of Americans with OUD at ~7 million)

This contributes to symptoms like brain fog, poor focus, low stress tolerance, and fatigue

Additionally, the expression of major histocompatibility complex class II (MHCII) molecules, especially HLA-DR, is elevated in microglia and peripheral monocytes and contributes, together with -syn-specific peptides, to T-cell activation and neuroinflammation [21]