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Generally follows the research-use only classification

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[16] According to NICE guidelines (CG61), IBS is diagnosed based on clinical criteria when patients experience abdominal pain or discomfort that has been present for at least 6 months, is associated with defecation or a change in bowel habit, and with at least two of the following: altered stool frequency, altered stool form, altered stool passage, mucus in stool, or bloating/distension

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It blocks that counter-signal, allowing bupropions appetite-reducing effect to stay switched on longer than it would on its own