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Vomiting occurs less frequently than nausea but may affect fifteen to twenty percent of patients, particularly those who experience severe nausea or those who do not implement dietary modifications to manage gastrointestinal symptoms
Nitric oxide promotes smooth muscle relaxation, and imbalanced NO signaling contributes to sphincter dysfunction
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A common dose is 1000 mcg daily, given either intramuscularly (IM) or subcutaneously
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