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In the cytoplasm and nucleus, Parkin functions as an E3 ubiquitin ligase
SAG mechanism : With enhanced lipophilicity, SAG crosses the lipid bilayer directly via passive diffusion
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At the same time, copper itself is a required cofactor for several angiogenic enzymes and transcriptional programs, and the GHK peptide appears to deliver copper in a biologically functional form at sites of cellular injury
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