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Depression or loss of motivation alongside fatigue may reflect mood changes from rapid metabolic shifts or from underlying mental health conditions unrelated to semaglutide

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Three GLP-1 injections have been FDA-approved for weight loss, including : FDA-approved oral weight loss medications include: Qsymia ( phentermine /topiramate) Contrave (naltrexone/bupropion) Xenical (orlistat) All of these require a prescription from a licensed healthcare provider

This led to the development and approval of specific versions of these drugs for chronic weight management