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The cryo-EM presence of the 100 M Pantethine treatment group suggests more empty-looking and elongated EVs (Fig

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These molecular differences may partly explain the poor translation of promising molecules from animal experiments to successful clinical trials

Inhibition of cysteine-glutamate transporter protein system (e.g., Erastin) will deplete intracellular GSH, eventually resulting in the inactivation of GPx4 and the accumulation of lipid peroxidation, which can induce cell ferroptosis to a certain extent [75]

[159] first discovered that DINO was required for P53-induced apoptosis