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3841 Unresolved Role of GLP-1RAs in Heart Failure with Reduced Ejection Fraction Unlike the positive results reported for GLP-1RAs in HFpEF, findings from dedicated trials in heart failure with reduced ejection fraction (HFrEF) report neutral findings
Some feel better in just a few hours, while others may see improvements in a day or two
Some compounding pharmacies do offer compounded versions marketed as Wegovy, though technically these are unapproved formulations of semaglutide
However, if you really want to take GLP-1 drugs for a lifetime, then adding high-dose omega-3 and polyphenols will make them work even better and will likely reduce some of their side effects
These include limited long-term safety data across diverse populations, insufficient understanding of mechanisms in neuropsychiatric and oncologic contexts, and suboptimal communication between clinicians and patients
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