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In slow transit-constipation , impaired regulation of peristalsis by the enteric nervous system and the muscles of the colon result in delayed passage of stool through the lower digestive tract
Sweeney et al., 2019
and disturbances in sexual function
Inappropriate p53 activation during development induces features of CHARGE syndrome
Dosing Approach: Many individuals remain at their initial dose for extended periods without increasing, focusing on consistency and tolerance rather than escalation
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