A.MiliN.CicalaC.SantiniA.CapassoR
By promoting its recycling, betaine thus helps to maintain this metabolic balance
To put that in perspective: if your therapeutic dose is 500 mcg, you'd theoretically need 500,000 mcg (500 mg) to approach potentially toxic levels
Reduces senescence-associated secretory phenotype burden: Senescent cells secrete inflammatory cytokines, chemokines, growth factors, and proteases collectively referred to as the senescence-associated secretory phenotype (SASP)
Current pharmacological strategies for UC primarily include 5-aminosalicylic acid (5-ASA), glucocorticoids, thiopurines, biological medications, and anti-cytokine therapies (Lamb et al., 2019