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This receptor is expressed in the pancreas (where it stimulates glucose-dependent insulin secretion), in the stomach (where it slows gastric emptying), and in certain regions of the central nervous system (where it decreases appetite)

For most patients, it delivers a similar magnitude of weight loss, provided the strict dosing routine is followed consistently.The reported average weight loss with Wegovy injection at the 7.2 mg dose is 20.7% of starting body weight over 72 weeks in the STEP-UP trial

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Various gut hormones, including glucagon-like peptide-1 (GLP-1), bile acids, leptin, FGF19 and ghrelin, play roles in the postprandial period and may exert anti-inflammatory effects [47, 50]