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The Billon 2025 paper (PMID 41421047) is the citation that anchors the route question: SLU-PP-915 was developed because SLU-PP-332 "lacks oral bioavailability." If the parent compound does not absorb orally, oral capsules and tablets are unlikely to produce the systemic ERR agonism seen in mice
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Image source Adequate stomach acid and enzymes are required to free B12 from the proteins it is bound to in food
Niacin can also have an antagonistic effect on gout medications: it elevates uric acid levels, which may counteract drugs like allopurinol or pegloticase that are meant to lower uric acid
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