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For example, if GLP-1 activation reduces appetite but also triggers compensatory reductions in metabolic rate, adding glucagon receptor activation that increases energy expenditure counteracts this adaptation

Hormone therapy is a medical treatment that involves the use of hormones to restore or balance the bodys natural hormone levels

NA, Not Applicable

Nausea (most common, typically dose-dependent and transient) Diarrhea or constipation during dose escalation Vomiting, especially when starting or increasing dose Reduced appetite and early satiety Injection site reactions (redness, bruising) Fatigue, particularly in early weeks Rare: Pancreatitis discontinue immediately with severe abdominal pain Rare: Thyroid C-cell effects (contraindicated with MEN2 or thyroid cancer history) Retatrutide (LY3437943) is Eli Lilly's triple GLP-1/GIP/glucagon receptor agonist in Phase III clinical trials