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The upregulation of glycolysis through c-Myc further facilitates the TCA cycle and OXPHOS in mitochondria

(2020, Drug Testing and Analysis) developed an immunopurification + high-resolution mass spectrometry method to detect Long R3-IGF-I and Des(1-3)-IGF-I in athlete samples establishing that IGF-1 LR3 is detectable by current anti-doping methods

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However, scientists still need larger human clinical trials to confirm its long-term safety and effectiveness