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During a period of high demand and limited supply, the FDA allowed pharmacies to compound GLP-1s to help patients maintain access while manufacturers scaled up production

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"We don't really know why some people only lose 5% where some people are super responders and losing 30% of their body weight." Kushner thinks of the result as a kind of new settling point the medication helps establish, though why it lands so much lower for some people isn't well understood

This is where personalized dosing protocolslike those offered by PlexusDxcan make a meaningful difference in tolerability and long-term adherence