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In TriNetX, propensity score matching is performed using observed baseline covariates, such that patients without documented laboratory values (eg, hemoglobin A1c or body mass index) are excluded from the matched cohorts in favor of individuals with available data

Older individuals may require lower doses of Semaglutide due to changes in their bodys ability to process medications

Rutagengwa, B

Non-peptidic oral GLP-1RAs may eventually reduce supply pressures because they do not require peptide synthesis or cold-chain storage, but this will depend on scalable, cost-efficient manufacturing pathways

This is because both compounds affect gastrointestinal motility and appetite through their respective mechanisms, and layering them too aggressively creates compounding GI effects that can derail compliance