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A recent small study found that reduced GLP-1 frequency may help people maintain their weight loss
Equally important is the proper storage of Semaglutide, as neglecting this raises the question of whether Semaglutide expires after 28 days, which can compromise the drugs efficacy
These results taken together suggest that adding even mild amounts of GR agonism (to increase energy expenditure) on top of a dual agonist like Tirzepatide is able to produce even more pronounced decreases in weight
Written by: Morgan Pennington , 01 Jul 2026 10 min read Reviewed and fact-checked: Niya Mansuri , Prescribing Pharmacist, GPhC No
Subjects from the PIONNEER 7 study showed comparable satisfaction between oral semaglutide and sitagliptin [41], a dipeptidyl peptidase-4 inhibitor (DPP-4i) largely used in monotherapy or combination when first-line treatment does not achieve adequate glycaemic control, but sitagliptin does not provide any cardiovascular benefit [95]
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