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Continuous administration of Matrine (100 mg/kg/d) for four weeks significantly increased the abundance of unclassified_Clostridia_UCG_014 and upregulated the expression of zonula occludens-1 (ZO-1) and occludin to enhance intestinal barrier function, thereby activating the HSP72 signaling pathway and alleviating CCl4-induced liver fibrosis via the "GM-liver-HSP72" axis [123]

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I dont typically like the mega doses of working up super high until people get an acid reflux response

Therefore, the results of the two studies are not directly comparable and not necessarily discordant

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