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Clinical trials revealed significant weight loss with liraglutide at doses of up to 3.0 mg per day, with participants losing an average of 46 kg over 20 weeks, outperforming placebo and orlistat (38)

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For example, in alveolar macrophages, GLP-1 receptor agonism suppressed activation of the NLRP3 inflammasome and reduced production of IL-1 [65], an effect in part mediated by the disruption of histone lactylation, a recognised regulator of pro-fibrotic gene expression [65]

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Before termination of treatment, cells were incubated with 5 M MitoSOX for 15 min at 37 C, and washed in PBS