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It has a long lasting prolonged effect
Direct provision of TMAO into diet has been shown to increase the development of atherosclerosis in animal models, confirming its pro-atherogenic properties 47 and multiple clinical studies have confirmed that an elevated TMAO level is associated with increased risks for incident major adverse CV events 48
In preclinical studies, compounds such as VX-765 and pralnacasan have demonstrated efficacy in inhibiting caspase-1 activation and protecting against inflammatory diseases
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A detailed description of the study design, recruitment of patients, inclusion and exclusion criteria, interventions, and previous study results are presented in recent publications ( 2.1 Subjects Briefly, 60 patients with depressive disorder aged 10-18 years and 20 age- and gender-matched healthy controls were included in this randomized, blinded, prospective study
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