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Back Hoet, JP (1953) 'Gustave Eduoard Laguesse: His demonstration of the significance of the Islands of Langerhans', Diabetes , 2,4, 322-24

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Users stopping retinoids frequently report rapid regression of benefits within 4-8 weeks including increased breakouts sometimes exceeding pre-treatment levels (retinoid rebound), accelerated fine line reappearance approaching or surpassing baseline, skin texture deterioration returning to pre-treatment roughness, and psychological dependency from dramatic visible decline creating pressure for continuous use despite side effect burden

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