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P450 enzymes are also involved in the first step of the methylation pathway, where they convert methionine to S-adenosylmethionine (SAMe)
Discussion Using a vitamin B 12 deficiency phenotype definition, consistent with previous reports [1, 2], there were 487 (6.8%) deficient individuals of White European ancestry receiving metformin in the UKB cohort out of a total of 7173
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When two groups were compared, the Students t -test or two-way ANOVA followed by Bonferronis post-hoc test was used
