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In pre-specified analyses at 52 weeks, participants who switched to orforglipron from Wegovy maintained their previously achieved weight loss with an average difference of 0.9 kg, while those who switched to orforglipron from Zepbound maintained their previously achieved weight loss with an average difference of 5.0 kg, using the efficacy estimand
The FDA-approved prescribing information for Wegovy permits abdominal injections specifically between the hip bones and below the rib cage
This provides a solid rationale for exploring their use in T1D, especially since overweight and obesity are common concerns in both types of diabetes
Contact your provider or seek emergency care if you experience: Seizures Severe mood changes (including worsening depression or suicidal thoughts) Hallucinations, paranoia, or confusion Rapid or irregular heartbeat Signs of an allergic reaction (such as a rash, swelling, or difficulty breathing) On top of the above, Wellbutrin carries an FDA black box warning about the potential for increased suicidal thoughts and behaviors in children, adolescents, and young adults
MG has received lecture fees from Menarini, RGM has no conflict of interest
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