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4F) and non-mitochondrial OCR (Fig

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Variants in GIPR (the GIP receptor relevant to tirzepatide's dual mechanism), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) are associated with measurably different response patterns to semaglutide and tirzepatide

Relative cell number of the indicated Jurkat SLC25A39 knockout cells expressing a vector control or SLC25A39 cDNA transduced with the indicated sgRNA