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Recent studies have found that increased level of GLP-1 in the hippocampus restores GABA and reverses this neurotoxic effect by reducing oxidative stress through the SIRT1/Nrf2/HO-1 pathway, promoting autophagy through the AMPK/mTOR pathway, and alleviating hippocampal apoptosis by inactivating pro-apoptotic kinase GSK-3 (Arab et al., 2023)

Future research should focus on the complex relationship between metabolic disturbances and AP, particularly the correlation between metabolic profiles, disease progression, and clinical outcomes

Receptor pharmacology has been characterised in detail

In conclusion, combination of metformin and liraglutide has synergistic protective effects on endothelial function

Instead of adding amino acids, DES removes the first three from the N-terminus, creating a truncated 67 amino acid peptide