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The significance of this paper is not only to compare the three routes of administration but also to evaluate them and determine which route is the best to administrate the drug

Restores healthy melatonin production and circadian rhythm regulation [3]

Larsen PJ, Tang-Christensen M, Holst JJ, Orskov C

Some patients anecdotally report better tolerance when taking their injection in the evening, though there is no evidence that timing affects the medication's efficacy