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Patients with primary hyperoxaluria type 2 have significant morbidity and require careful follow-up
In HHcy C57BL/6 mouse model cultured with high methionine diet or drinking water supplemented with Hcy (1.8 g/L) and blood samples collected from HHcy, researchers found that Hcy promoted H 2 O 2 accumulation by activating the HIF1-ERO1 pathway, causing ER peroxidation and ERS
Tanner staging by a qualified clinician
Stools may become infrequent and harder to pass
In brief, animals were decapitated under deep anesthesia at the final phase of the experiment
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