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Diverticulitisinflammation of small pouches in the colonaffects nearly 200,000 Americans annually and creates unique challenges for weight loss medication selection

Metformin IR is taken twice daily, while the extended-release formulation allows once-daily dosing

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Peripherally circulating GLP-1 (143) and some GLP-1RAs, such as liraglutide and semaglutide (145), can readily access the CVOs, including the subfornical organ and the area postrema, which express GLP-1R and have close neuroanatomical connections with hypothalamus involved in forage and satiety control