Phagocytosed photoreceptor outer segments are highly enriched in polyunsaturated fatty acids and are the major source of intracellular ROS generation in RPE 3,4
In PIONEER 1 and 9 where semaglutide was used as monotherapy, patients were previously treated with diet and exercise, or an OAD (in PIONEER 9) that required a wash-out period
But as Francis Colonna, a senior obesity medicine nurse practitioner at Northwell Health, points out, it can be taken at any time of day, with or without food or water restrictions
The sc infusion was necessary because the GLP-1 molecule is cleared extremely rapidly in the body (intravenous (IV) half-life of 1-2 min.) due to the actions of an enzyme, dipeptidyl peptidase 4 (DPP-4), which inactivates the peptide [13]
Never guess at a concentration