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You may also like Product Description PT-141 Peptide | Buy PT-141 UK | Research Use Only PT-141 also known as Bremelanotide and Vyleesi (FDA-approved pharmaceutical formulation) is a synthetic cyclic heptapeptide (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH, MW 1,025.2 Da) originally derived as an active metabolite of Melanotan II and engineered as a non-selective melanocortin receptor agonist with highest affinity for MC4R, acting centrally in the medial preoptic area and paraventricular nucleus of the hypothalamus to modulate dopaminergic, noradrenergic, and serotoninergic neurotransmission governing sexual desire and arousal making it the only CNS-acting melanocortin system research tool with a full Phase II and Phase III clinical evidence base, FDA approval (2019) as Vyleesi for hypoactive sexual desire disorder in premenopausal women, and a pharmacological profile mechanistically distinct from PDE5 inhibitors operating upstream on the neural circuitry of desire rather than downstream on vascular nitric oxide pathways

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Starting at a lower dose significantly reduces the risk of nausea and GI side effects during the adjustment period

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The impact on weight accumulates while the drug is titrated to a maintenance dose, occurring every four weeks in these studies