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The elderly (reduced absorption) Pernicious anemia Vegetarians / Vegans (low dietary B12) People taking metformin or acid reflux medications (PPIs) Post-bariatric or gastric-bypass patients Genetic variants in MTRR , MTR , or TCN2 What Has B12 Been Studied For
Because these agents inhibit transmission in both sympathetic and parasympathetic ganglia, physiological effects reflect blockade of the predominant resting autonomic tone, including tachycardia (cardiac) and marked orthostatic hypotension (vascular) (middle panel)
Inflammation Res 63, 519525
e-mail: [email protected] This article was submitted to Frontiers in Plant Metabolism and Chemodiversity, a specialty of Frontiers in Plant Science
In the vascular wall, it functions as an enzyme modulator that upregulates eNOS and downregulates NADPH oxidase
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