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Furthermore, hesperidin was found to increase Nrf2 protein expression, combating gentamicin-induced nephrotoxicity 106 , and diethylnitrosamine/CCl 4 -induced renal repercussions 107
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In reaction order these enzymes are GTP cyclohydrolase 1 (GTPCH), 6-pyruvoyltetrahydropterin synthase (PTPS), and sepiapterin reductase (SR)
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