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Due to its ubiquitous nature and presence in all cells, PEA has wide-ranging therapeutic applications

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These possible adverse outcomes should be considered alongside the potential metabolic health benefits during the decision-making process for each individual considering metabolic surgery (Arterburn 2020)

The five subtypes (MC1R to MC5R) are class A G-protein-coupled receptors that signal principally through Gs and adenylyl cyclase to raise intracellular cAMP, and the conserved His-Phe-Arg-Trp core of alpha-MSH is the message sequence recognised by the binding pocket