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Hutchesson, Cheryce L
Under hypoxic conditions, HIF-1-induced lactate alters intracellular pH, reduces the release of free Fe 2 , and enhances the SLC7A11 system, thereby increasing cellular resistance to ferroptosis [63]
Although this provides substrates for cellular metabolism, it also significantly promotes the abnormal accumulation of ROS
For the HEDS assays, either GSH was varied between 100 M and 1.5 mM for ScGrx (or 250 M and 3.0 mM for PfGrx) at fixed concentrations of HEDS (0.18, 0.37, 0.55 and 0.74 mM) or HEDS was varied between 90 and 920 M at fixed concentrations of GSH (0.3, 0.5, 1 and 1.5 mM for ScGrx7 or 0.25, 0.5, 1 and 2 mM for PfGrx)
Glutathion-S-Transferasen (GST) katalysieren die Konjugation von GSH mit elektrophilen Toxinen, Arzneimitteln und Metaboliten wodurch hydrophile Konjugate entstehen, die leicht ber die Nieren oder die Galle ausgeschieden werden knnen
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