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Ferritin, a 24-subunit nanocage complex comprising ferritin light chain (FTL) and ferritin heavy chain 1 (FTH) polypeptides, functions as the primary intracellular iron storage protein to inhibit ferroptosis at the cellular level through two key mechanisms: (1) iron sequestration: the ferroxidase activity of FTH causes up to 4,500 iron atoms to mineralize within its cavity and oxidize Fe 2+ to Fe 3+

The hydroxyl moiety combines with the peroxyl radical (ROO ) via a coordinated pathway from the phenol to the radical, resulting in a transition state with an H-O bond containing one electron [204]

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At 52 weeks, participants who switched from Wegovy to oral orforglipron experienced an average weight regain of only 0.9 kg