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Moving forward, understanding proteostasis at a systems level, as an interactome rather than a pathway, will be essential for decoding disease mechanisms and designing truly effective therapeutic interventions
Gastrointestinal Effects : The dual-action mechanism may cause different GI side effects
Sensitivity analyses confirmed that the cardioprotective effect of GLP-1RAs is largely independent of glycaemic status, suggesting a direct cardiovascular benefit in patients with diabetes
Even at microdoses, semaglutide improves insulin sensitivity for many patients
While they are effective for many, they can cause side effects, including diarrhea
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