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doi: 10.1161/CIRCULATIONAHA.106.652859 65

By targeting two hormones involved in appetite regulation and glucose control, Tirzepatide offers a dual approach to weight management, leading to greater efficacy in weight loss and metabolic improvements

Hepatic 25-hydroxylation via cytochrome P450 isoform CYP2R1 converts cholecalciferol to 25(OH)D, followed by renal 1-hydroxylation through CYP27B1 to yield bioactive 1,25(OH)2D [153]

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cDNA was synthesized from 1 g RNA using a fPrime-Script RT Reagent Kit with gDNAEraser (Takara, Japan)